IL-10 -1082 A/G (rs1800896) Polymorphism is Effective in Clearing Hepatitis B Virus Infection

Background: Hepatitis B Virus (HBV) is a universal health challenge all around the world. Several factors like viral load, genetic characteristics, age, sex, and immune status contribute to variable clinical outcomes of HBV infection. The sequels infection vary remarkably among persons ranging from spontaneous deletion persistent Objective: present study aimed evaluate association single nucleotide polymorphisms IL10-1082 with clearance. Methods: Sixty subjects Chronic (CHB) 60 who spontaneously recovered were enrolled in study. IL-10-1082 determined by Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR–RFLP). Results: clearance demonstrated significant GG genotype (P = 0.03), while there was no other genotypes. Reduced risk chronic hepatitis associated (OR: 2.33, 95% CI: 1.07 - 5.09). Besides, A/G alleles did not differ clearly between two groups 0.07) Conclusions: may be reduced CHB recovery after